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Figure 2 | Molecular Medicine

Figure 2

From: Brown Adipose Tissue Responds to Cold and Adrenergic Stimulation by Induction of FGF21

Figure 2

FGF21 mRNA levels are induced in BAT of wild-type C57BL/6J mice after stimulation with the β3-adrenergic agonist CL316243. Mice were either exposed to 4°C for 4 h or injected intraperitoneally (2 mg/kg body weight) with CL316243, 4 h before harvesting BAT. mRNA levels for FGF21 (A), PGC-1α (B) and PPARα (C) were measured by quantitative RT-PCR. Bars show means ± SEM of eight mice per group. Data were analyzed by one-way ANOVA. Statistically significant differences between control mice and mice exposed to 4°C or CL316243 are shown (*P < 0.001).

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