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Figure 6 | Molecular Medicine

Figure 6

From: Macrophage Migration Inhibitory Factor Mediates Hypoxia-Induced Pulmonary Hypertension

Figure 6

Increased hypoxia-induced cell proliferation in primary murine lung fibroblasts. Lung fibroblasts were obtained from wildtype (mif+/+) and MIF-deficient mice (mif−/−) mice. mif+/+ cells significantly increased proliferation in 1% oxygen, whereas mif−/− fibroblasts did not. However, mif−/− cells grown in hypoxia and supplemented with medium from hypoxic mif+/+ cell cultures increased growth. This increased proliferation was inhibited by ISO-92, but not the vehicle DMSO. Data represents at least 3 independent experiments: *P < 0.05; **P < 0.01; ns, nonsignificant; N, normoxia; H, hypoxia.

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