Figure 7
From: Macrophage Migration Inhibitory Factor Mediates Hypoxia-Induced Pulmonary Hypertension
ISO-92 reduction of pulmonary vascular remodeling and hypertension in the mouse hypoxia model. Mice housed in an atmosphere of 10% oxygen were continuously administered either ISO-92 (1.8 mg/kg/d) or vehicle via an osmotic delivery device inserted subcutaneously on the dorsum of the animal. Inhibition of MIF significantly reduced all indications of pulmonary vascular remodeling: (A) vascular wall thickness, (B) right ventricle hypertrophy and (C) right ventricular systolic pressure. n = 5/group, *P < 0.05, **P < 0.01 versus vehicle control. 
, Control; 
, ISO-92.