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Table 3 Fatty acid composition of lipid rafts from control subjects, PD and iPD.

From: Severe Alterations in Lipid Composition of Frontal Cortex Lipid Rafts from Parkinson’s Disease and Incidental Parkinson’s Disease

  NSL PD iPD
Fatty acids    
14:0 0.52 ± 0.04 0.62 ± 0.07 0.58 ± 0.04
14:1 0.13 ± 0.10ab 0.18 ± 0.08a 0.00 ± 0.00b
15:0 0.91 ± 0.14ab 1.42 ± 0.06a 0.42 ± 0.15b
15:1 0.10 ± 0.03a 0.17 ± 0.04a 0.00 ± 0.00b
16:0 DMA 1.82 ± 0.25 1.73 ± 0.26 1.44 ± 0.15
16:0 24.10 ± 1.31b 28.66 ± 2.07ab 31.98 ± 1.06a
16:1 1.08 ± 0.08b 3.94 ± 0.63a 1.17 ± 0.13b
16:2 0.20 ± 0.03b 0.53 ± 0.21ab 0.39 ± 0.02a
17:0 0.31 ± 0.01a 0.36 ± 0.02a 0.05 ± 0.03b
17:1 0.05 ± 0.02b 0.35 ± 0.12a 0.00 ± 0.00b
18:0 DMA 3.47 ± 0.11a 1.54 ± 0.20b 3.75 ± 0.27a
18:1n-9 DMA 0.76 ± 0.13a 0.84 ± 0.09a 0.29 ± 0.05b
18:1n-7 DMA 1.49 ± 0.38a 0.79 ± 0.16ab 0.56 ± 0.12b
18:0 22.05 ± 0.43b 26.35 ± 0.73a 28.18 ± 0.65a
18:1 n-9 17.64 ± 1.10a 14.88 ± 1.33a 10.09 ± 0.53b
18:2 n-6 0.85 ± 0.09a 0.38 ± 0.06b 0.50 ± 0.10b
20:1 1.08 ± 0.19 1.25 ± 0.19 0.68 ± 0.09
20:2 n-6 0.13 ± 0.04 0.07 ± 0.04 0.04 ± 0.03
20:3 n-6 0.53 ± 0.02a 0.31 ± 0.05b 0.44 ± 0.06ab
20:4 n-6 3.70 ± 0.18a 1.47 ± 0.12b 1.26 ± 0.26b
22:2 n-6 0.68 ± 0.09b 2.77 ± 0.36a 1.63 ± 0.28b
23:0 2.40 ± 0.12a 1.21 ± 0.12b 1.32 ± 0.12b
22:5 n-6 0.46 ± 0.06a 0.09 ± 0.04b 0.08 ± 0.04b
22:5 n-3 0.14 ± 0.03a 0.06 ± 0.03ab 0.01 ± 0.01b
22:6 n-3 6.87 ± 0.34a 1.71 ± 0.22b 1.41 ± 0.41b
Totals    
Saturates 53.86 ± 1.53b 61.04 ± 2.41a 66.96 ± 1.56a
n-3 7.11 ± 0.37a 2.10 ± 0.24b 1.95 ± 0.47b
n-6 6.35 ± 0.24a 5.11 ± 0.48b 4.18 ± 0.20b
n-9 19.63 ± 1.26a 17.33 ± 1.27a 10.88 ± 0.58b
n-3 LCPUFA 7.11 ± 0.37a 2.10 ± 0.24b 1.91 ± 0.46b
Monoenes 28.92 ± 1.65a 29.21 ± 2.53a 21.18 ± 0.97b
Ratios    
n-3/n-6 1.12 ± 0.05a 0.42 ± 0.03b 0.45 ± 0.08b
18:1/n-3 LCPUFA 2.57 ± 0.22b 8.26 ± 1.81a 7.35 ± 1.77a
Saturates/n-3 7.75 ± 0.40b 31.62 ± 3.43a 47.01 ± 9.72a
Saturates/n-9 2.91 ± 0.26b 3.71 ± 0.37b 6.28 ± 0.36a
Indices    
Unsaturation index 93.73 ± 5.07a 57.35 ± 2.47b 44.86 ± 3.52c
Peroxidability index 73.88 ± 3.35a 26.70 ± 2.41b 23.08 ± 4.48b
  1. Results are expressed as mole % and represent means ± SEM. Values in the same row bearing different letters are significantly different (P < 0.05). Unsaturation and peroxidability indices were calculated following the equations in Cosgrove et al. (63).