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Table 4 Lipid class composition of lipid rafts from control subjects, PD and iPD.

From: Severe Alterations in Lipid Composition of Frontal Cortex Lipid Rafts from Parkinson’s Disease and Incidental Parkinson’s Disease

 

NSL

PD

iPD

Sphingomyelin

11.43 ± 1.44

8.05 ± 0.64

10.30 ± 1.52

PC

5.35 ± 0.49

6.42 ± 0.49

7.11 ± 0.76

PS

6.82 ± 0.50b

7.54 ± 0.55ab

9.31 ± 0.46a

PI

2.16 ± 0.17b

2.20 ± 0.20b

3.00 ± 0.24a

Phosphatidylglycerol

0.70 ± 0.10

0.86 ± 0.19

1.09 ± 0.21

PE

20.97 ± 0.57b

23.54 ± 0.36a

22.14 ± 0.53ab

Sulfatides

10.56 ± 0.68a

10.35 ± 0.98ab

7.37 ± 0.84b

Cerebrosides

5.10 ± 0.79a

5.98 ± 0.69a

2.52 ± 0.60b

Diacylglycerols

0.00 ± 0.00

0.00 ± 0.00

0.0 ± 0.0

Cholesterol

33.04 ± 1.18

30.43 ± 1.17

35.16 ± 1.96

Free fatty acids

2.17 ± 0.28a

2.70 ± 0.32a

0.88 ± 0.31b

Triglycerides

0.00 ± 0.00

0.00 ± 0.00

0.00 ± 0.00

Sterol esters

1.68 ± 0.60

1.94 ± 0.31

1.11 ± 0.57

Neutral lipids

36.90 ± 1.41

35.08 ± 1.23

37.15 ± 1.35

Polar lipids

63.09 ± 1.41

64.92 ± 1.23

62.85 ± 1.35

Phospholipid/cholesterol

1.11 ± 0.06b

1.35 ± 0.09a

1.26 ± 0.12ab

  1. Results are expressed as mole % and represent means ± SEM. Values in the same row bearing different letters are significantly different (P < 0.05).