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Table 4 Lipid class composition of lipid rafts from control subjects, PD and iPD.

From: Severe Alterations in Lipid Composition of Frontal Cortex Lipid Rafts from Parkinson’s Disease and Incidental Parkinson’s Disease

  NSL PD iPD
Sphingomyelin 11.43 ± 1.44 8.05 ± 0.64 10.30 ± 1.52
PC 5.35 ± 0.49 6.42 ± 0.49 7.11 ± 0.76
PS 6.82 ± 0.50b 7.54 ± 0.55ab 9.31 ± 0.46a
PI 2.16 ± 0.17b 2.20 ± 0.20b 3.00 ± 0.24a
Phosphatidylglycerol 0.70 ± 0.10 0.86 ± 0.19 1.09 ± 0.21
PE 20.97 ± 0.57b 23.54 ± 0.36a 22.14 ± 0.53ab
Sulfatides 10.56 ± 0.68a 10.35 ± 0.98ab 7.37 ± 0.84b
Cerebrosides 5.10 ± 0.79a 5.98 ± 0.69a 2.52 ± 0.60b
Diacylglycerols 0.00 ± 0.00 0.00 ± 0.00 0.0 ± 0.0
Cholesterol 33.04 ± 1.18 30.43 ± 1.17 35.16 ± 1.96
Free fatty acids 2.17 ± 0.28a 2.70 ± 0.32a 0.88 ± 0.31b
Triglycerides 0.00 ± 0.00 0.00 ± 0.00 0.00 ± 0.00
Sterol esters 1.68 ± 0.60 1.94 ± 0.31 1.11 ± 0.57
Neutral lipids 36.90 ± 1.41 35.08 ± 1.23 37.15 ± 1.35
Polar lipids 63.09 ± 1.41 64.92 ± 1.23 62.85 ± 1.35
Phospholipid/cholesterol 1.11 ± 0.06b 1.35 ± 0.09a 1.26 ± 0.12ab
  1. Results are expressed as mole % and represent means ± SEM. Values in the same row bearing different letters are significantly different (P < 0.05).