Human Skeletal Muscle Stem Cell Antiinflammatory Activity Ameliorates Clinical Outcome in Amyotrophic Lateral Sclerosis Models

Table 1 Gene and protein expression profile of human SkmSC-transplanted Wr CNS.

Human antiinflammatory cytokines and receptors
Gene			Fold difference	P
Decreased gene expression
CCL2			−5.5996	0.000189
CXCL2			−255.7635	0.004607
CXCL6			−447.3727	0.003429
IL-1R1			−563.6543	0.00016
Increased gene expression
IL-10			4812.82	0.000001
IL-10RA			950.582	0.015
IL-13			21658.8	0.015
Bio-Plex cytokine assay
		Average
Protein	fluorescence intensity		SD	P
IL-13		9.82	0.606	0.038611
IL-10		0.56	0.737	0.18

Gene expression profile: Results are expressed in fold change signal between in vitro SkmSCs, vehicle-treated Wr CNS and SkmSC-transplanted Wr CNS. Values are expressed as mean ± SD. P < 0.05 for human SkmSC-transplanted Wr CNS versus human SkmSCs cultured in vitro. Protein expression profile: Results are expressed in average fluorescence intensity signal between SkmSC-transplanted Wr CNS and vehicle-treated Wr CNS. Values are expressed as mean ± SD. P< 0.05 for human SkmSC-transplanted Wr CNS versus vehicletreated Wr CNS.

ISSN: 1528-3658