Figure 6

Vascular repair induced by MAC delivery was blocked by CXCR2 inhibitor SB225002. Flat mounted retina microvasculature was stained green with isolectin, and avascular areas (insets) are outlined in white. A representative retina per group is shown: (A) ischemic retina at P12; (B) vehicle-injected retina at P15; (C) MAC-injected retina at P15; (D) MAC-injected retina at P15 in mouse that received SB225005 intraperitoneal injections; (E) vehicle-injected retina at P15 in mouse that received SB225005 intraperitoneal injections; (F) quantification of avascular areas shows that SB225005 significantly inhibited MAC proangiogenic effects. N = 7; ***p < 0.001; ns: not significant.