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Figure 4 | Molecular Medicine

Figure 4

From: Adipocyte Enhancer-Binding Protein 1 (AEBP1) (a Novel Macrophage Proinflammatory Mediator) Overexpression Promotes and Ablation Attenuates Atherosclerosis in ApoE−/− and LDLR−/− Mice

Figure 4

Atherogenesis is significantly attenuated in LDLR−/−/KO-BM mice compared with LDLR−/−/WT-BM mice. (A) Experimental design of generation of radiation chimera and list of chimeras. (B) En face analysis of aorta atherosclerotic lesion formation in LDLR−/−/WT-BM (n = 8) and LDLR−/−/KO-BM (n = 6) chimeras. Lipid staining was performed using the sudan IV reagent. Quantification of atherosclerotic lesion area was performed with ImageJ; the numbers represent atherosclerotic lesion as a percentage of total aorta area (*P = 0.0268). (C) Quantification of atherosclerotic lesions of aortic roots in LDLR−/−/ WT-BM(n = 8) and LDLR−/−/KO-BM(n = 6) chimeras. Atherosclerotic lesion size at the aortic sinus as a percentage of total aortic root area (*P = 0.05) is shown. (D) Plasma cholesterol levels of LDLR−/−/WT-BM(n = 8) and LDLR−/−/KO-BM(n = 6) chimeras after 16 wks of atherogenic diet feeding. Error bars represent SEM (P = 0.07). (E) Plasma triglycerides levels of LDLR−/−/WT-BM(n = 8) and LDLR−/−/KO-BM(n = 6) chimeras after 16 wks of atherogenic diet feeding. Error bars represent SEM (**P = 0.006).

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Molecular Medicine

ISSN: 1528-3658