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Figure 4 | Molecular Medicine

Figure 4

From: α-1-Antitrypsin Gene Delivery Reduces Inflammation, Increases T-Regulatory Cell Population Size and Prevents Islet Allograft Rejection

Figure 4

Circulating pEF-hAAT-derived hAAT modifies posttransplantation foxp3 Treg cell population. (A) Mice were grafted intraperitoneally with allogeneic skin tissue, and splenic Treg cell population size was assessed 7 d after transplantation. Control (nontransplanted mice): CT, background Treg cell population size in mice that were not injected by HD tailvein injection (n = 6); pEF-hAAT, Treg cell population size from mice that were HD tail-vein injected with pEF-hAAT (n = 6). Transplantation (skin-tissue graft): PBS, allogeneic skin-tissue transplantation into mice that were HD tail-vein injected with PBS (n = 6). pEF-hAAT, allogeneic skin-tissue transplantation into mice that were HD tail-vein injected with pEF-hAAT (n = 6). Treg cell population size was assessed by FACS after CD4-positive T-cell enrichment. Mean ± SEM; *P> 0.05. (B) Representative FACS analysis images (y axis: forward scatter (FSC); x axis: Foxp3-GFP).

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Molecular Medicine

ISSN: 1528-3658