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Table 2 Effect of RSVA405 administration on body weight of mice fed an HFD.

From: Small-Molecule Activators of AMP-Activated Protein Kinase (AMPK), RSVA314 and RSVA405, Inhibit Adipogenesis

Week(s) of treatment Standard diet HFD HFD + RSVA405 (20 mg/kg/d) HFD + RSVA405 (100 mg/kg/d)
1 20 ± 1.6 18.2 ± 0.9 18.4 ± 1.1 18.5 ± 1.1
2 22.2 ± 1.8 23 ± 0.7 22 ± 1 22.3 ± 1
3 23.4 ± 1.8 27.3 ± 0.5a 24.3 ± 1.36b 24.6 ± 1.4c
4 24.5 ± 2.4 29 ± 0.4a 27.1 ± 2.2c 25.9 ± 1.9c
5 25.8 ± 2.9 31.4 ± 0.8a 30.2 ± 2.2 28.4 ± 1.9c
6 27.6 ± 3.5 34.7 ± 1.1d 33 ± 2.3c 30.4 ± 2.1c
7 28.4 ± 3.2 37.2 ± 1.1d 34.8 ± 3.1c 32.8 ± 2.2c
8 28.7 ± 3.2 40.7 ± 1.4e 36.4 ± 2.3c 35.4 ± 2.3c
9 29.7 ± 3.2 42.8 ± 1.6e 38.4 ± 2.3c 36.8 ± 2.6b
10 31 ± 3.2 45.2 ± 1.4e 39.9 ± 2.5c 38.6 ± 2.6b
11 32.4 ± 3.2 46.5 ± 1.2e 42 ± 2.4c 40.8 ± 3c
  1. Data are mean ± SD. n = 5.
  2. aP < 0.05, dP < 0.01, eP < 0.001, versus standard diet condition. bP < 0.01, cP < 0.05, versus HFD condition.