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Table 2 Effect of RSVA405 administration on body weight of mice fed an HFD.

From: Small-Molecule Activators of AMP-Activated Protein Kinase (AMPK), RSVA314 and RSVA405, Inhibit Adipogenesis

Week(s) of treatment

Standard diet

HFD

HFD + RSVA405 (20 mg/kg/d)

HFD + RSVA405 (100 mg/kg/d)

1

20 ± 1.6

18.2 ± 0.9

18.4 ± 1.1

18.5 ± 1.1

2

22.2 ± 1.8

23 ± 0.7

22 ± 1

22.3 ± 1

3

23.4 ± 1.8

27.3 ± 0.5a

24.3 ± 1.36b

24.6 ± 1.4c

4

24.5 ± 2.4

29 ± 0.4a

27.1 ± 2.2c

25.9 ± 1.9c

5

25.8 ± 2.9

31.4 ± 0.8a

30.2 ± 2.2

28.4 ± 1.9c

6

27.6 ± 3.5

34.7 ± 1.1d

33 ± 2.3c

30.4 ± 2.1c

7

28.4 ± 3.2

37.2 ± 1.1d

34.8 ± 3.1c

32.8 ± 2.2c

8

28.7 ± 3.2

40.7 ± 1.4e

36.4 ± 2.3c

35.4 ± 2.3c

9

29.7 ± 3.2

42.8 ± 1.6e

38.4 ± 2.3c

36.8 ± 2.6b

10

31 ± 3.2

45.2 ± 1.4e

39.9 ± 2.5c

38.6 ± 2.6b

11

32.4 ± 3.2

46.5 ± 1.2e

42 ± 2.4c

40.8 ± 3c

  1. Data are mean ± SD. n = 5.
  2. aP < 0.05, dP < 0.01, eP < 0.001, versus standard diet condition. bP < 0.01, cP < 0.05, versus HFD condition.