Figure 2From: Sorafenib-Induced Apoptosis of Chronic Lymphocytic Leukemia Cells Is Associated with Downregulation of RAF and Myeloid Cell Leukemia Sequence 1 (Mcl-1)Sorafenib is cytotoxic for CLL cells from fludarabine refractory patients. CLL B cells purified from freeze-thawed PBMCs from four fludarabine-refractory CLL patient samples were cocultured in the presence of NLCs (A) or MSCs (B) with a single dose of 10 µmol/L sorafenib or 10 µmol/L fludarabine (F-ara-A) or DMSO added once at the beginning of the culture. CLL cell viability was measured as above. Data shown are mean ± SD from four different CLL samples. Statistical significance was determined using a paired Student t test.Back to article page