Table 3 Examples of the half-angel half-devil role of NK cells during bacterial infections.
From: Natural Killer (NK) Cells in Antibacterial Innate Immunity: Angels or Devils?
Role of NK cells and experimental model | Proof for NK cell role | Reference |
|---|---|---|
Beneficial | Â | Â |
M. avium | NK cell lysis of infected monocytes, NK cell lysis of infected macrophages, Anti-NK1.1 depletion | Katz et al. J. Clin. Immunol. 1990, 10, 71a; Bermudez et al. J. Leuk. Biol. 1990, 47, 135; Harshan et al. Infect. Immun. 1991, 59, 2818 |
Mycobacterium lepraemurium | NK cell lysis of infected macrophages | Denis Int. J. Immunopharmacol. 1991, 13, 881 |
Mycobacterium tuberculosis | Lysis of infected MØ by NK cells, Rag KO mice | Vankayalapati et al. J. Immunol. 2005, 175, 4611; Feng et al. J. Immunol. 2006, 177, 7086 |
Mycobacterium bovis | IL-15 transgenic mice, reduced intracellular bacterial growth | Umemura et al. J. Immunol. 2001, 167, 946; Denis et al. Tuberculosis. 2007, 87, 53 |
L. monocytogenes | Anti-NK cell depletion | Dunn and North Infect. Immun. 1991, 59, 2892 |
S. typhimurium | Anti-asialo GM-1 depletion | Schafer et al. Infect. Immun. 1992, 60, 791 |
Salmonella choleraesuis | Anti-IL-15 administration | Hirose et al. J. Leuk. Biol. 1999, 66, 382 |
Salmonella enterica | Anti-NK1.1 depletion | Ashkar et al. Infect. Immun. 2009, 77, 214 |
Chlamydia trachomatis | Anti-asialo GM-1 depletion, lysis of infected epithelial cells | Tseng et al. Infect. Immun. 1998, 66, 5867; Hook et al. Clin. Exp. Immunol. 2004, 138, 54 |
Chlamydia muridarum | Anti-asialo GM-1 depletion | Jiao et al. J. Immunol. 2011, 187, 401 |
Staphylococcus aureus | Anti-NK1.1 depletion, IL-15 KO mice | Nilsson et al. Clin. Exp. Immunol. 1999, 117, 63; Small et al. J. Immunol. 2008, 180, 5558 |
Polymicrobial peritonitis | Anti-asialo GM-1 depletion | Godshall et al. Shock. 2003, 19, 144 |
Bordetella pertussis | Anti-asialo GM-1 depletion | Byrne et al. Eur. J. Immunol. 2004, 34, 2579 |
Chlamydophila abortus | Anti-asialo GM-1 depletion | Buendia et al. J. Comp. Path. 2004, 130, 48 |
Shigella flexneri | Rag KO mice | Le-Barillec et al. J. Immunol. 2005, 175, 1735 |
Legionella pneumophila | Anti-asialo GM-1 depletion | Spörri et al. J. Immunol. 2006, 176, 6162 |
Haemophilus influenza | IL-15 KO mice | Miyazaki et al. J. Immunol. 2007, 179, 5407 |
Pseudomonas aeruginosa | NKG2D activation and bacterial clearance | Wesselkamper et al. J. Immunol. 2008, 1891, 5481 |
Francisella tularensis | Anti-asialo GM1 depletion (granuloma formation) | Bokhari et al. Infect. Immun. 2008, 76, 1379 |
Deleterious | Â | Â |
Pseudomonas aeruginosa | Anti-NK1.1 depletion, role of NKG2D in epithelial cell injury | Newton et al. Nat. Immun. 1992, 11, 335; Borchers et al. Infect. Immun. 2006, 74, 2578 |
L. monocytogenes | Anti-NK1 + depletion | Teixeira and Kaufmann J. Immunol. 1994, 152, 1873 |
LPS-induced Shwarzman reaction | Anti-NK1.1 or anti-asialo GM-1 | Heremans et al. Eur. J. Immunol. 1994, 24, 1155 |
LPS-induced lethal shock | NK1 + cells depletion | Emoto et al. J. Immunol. 2002, 169, 1426 |
E. coli | Anti-asialo GM-1 depletion | Badgwell et al. Surgery. 2002, 132, 205 |
Polymicrobial peritonitis | β2M KO + anti-asialo GM-1, anti-NK1.1 or anti-asialo GM-1 | Sherwood et al. Lab. Invest. 2004, 84, 1655; Etogo et al. J. Immunol. 2008, 180, 6334 |
Severe sepsis | Enhanced levels of Granzyme | Zeerleder et al. Clin. Immunol. 2005, 116, 158 |
Streptococcus pyogenes | Anti-asialo GM-1 depletion | Goldmann et al. J. Infect Dis. 2005, 191, 1280 |
Streptococcus pneumoniae | Scid mice + anti-asialo GM-1 | Kerr et al. Microbes Infect. 2005, 7, 845 |
H. pylori | Increased infiltration of NK cells | Kuo et al. World J. Gastroenterol. 2005, 11, 4357 |
Mycobacteria induced-colitis | IL-10 KO mice | Singh et al. BMC Immunol. 2008, 9, 25 |
Ehrlichia chaffeensis | NK cell depletion | Stevenson et al. Am. J. Pathol. 2010, 177, 766 |