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Figure 4 | Molecular Medicine

Figure 4

From: Effect of Cigarette Smoke Exposure and Structural Modifications on the α-1 Antitrypsin Interaction with Caspases

Figure 4

Caspase-3 inhibitory effect of ZZ-A1AT in vivo. (A) Endogenous lung caspase-3/7 activity measured in a fluorescence activity assay at 3 d following CS exposure in mice. Mice instilled with ZZ-A1AT-expressing AAV, but not those instilled with control AAV, exhibited inhibition of CS-induced caspase-3 activity in the lung (mean + SEM; *P < 0.05; n = 3–5). (B) Zymogram of lung lysates from mice instilled with control vehicle (PBS), control AAV or ZZ-A1AT-expressing AAV exposed to air control or to CS for 3 d. hPC is a positive control (human fibrosarcoma whole cell lysate).

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Molecular Medicine

ISSN: 1528-3658