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Table 1 IGHD gene RF usage and hydropathicity in productively rearranged IGHD-IGHJ (D-J) versus productive IGHV-IGHD-IGHJ (V-D-J) in CLL and ALL.

From: Partial versus Productive Immunoglobulin Heavy Locus Rearrangements in Chronic Lymphocytic Leukemia: Implications for B-Cell Receptor Stereotypy

  D-J in CLL V-D-J in CLLa D-J in ALL V-D-J in ALLa
IGHD RF     
RF1 73 (36.1) 40 (20.8) 48 (34.5) 14 (28.6)
RF2 64 (31.7) 100 (52.1)b 43 (31.0) 17 (34.7)
RF3 65 (32.2) 52 (27.1) 48 (34.5) 18 (36.7)
IGHD RF     
Hydrophilic RF 70 (34.6) 118 (61.5)b 51 (36.7) 18 (36.7)
Hydrophobic RF 69 (34.2) 51 (26.6) 45 (32.3) 22 (44.9)
RF with stop codon(s) 63 (31.2) 23 (11.9) 43 (31.0) 9 (18.4)
  1. Data are n (%).
  2. aIn 6 of 198 and 4 of 53 V-D-J in CLL and ALL, respectively, the IGHD gene was not determined.
  3. bStatistically significant higher frequency for RF2 and hydrophilic RF was observed in productive V-D-J junctions versus productively rearranged D-J joints in CLL (P < 0.001 for both comparisons).