Partial versus Productive Immunoglobulin Heavy Locus Rearrangements in Chronic Lymphocytic Leukemia: Implications for B-Cell Receptor Stereotypy

Table 1 IGHD gene RF usage and hydropathicity in productively rearranged IGHD-IGHJ (D-J) versus productive IGHV-IGHD-IGHJ (V-D-J) in CLL and ALL.

	D-J in CLL	V-D-J in CLL^a	D-J in ALL	V-D-J in ALL^a
IGHD RF
RF1	73 (36.1)	40 (20.8)	48 (34.5)	14 (28.6)
RF2	64 (31.7)	100 (52.1)^b	43 (31.0)	17 (34.7)
RF3	65 (32.2)	52 (27.1)	48 (34.5)	18 (36.7)
IGHD RF
Hydrophilic RF	70 (34.6)	118 (61.5)^b	51 (36.7)	18 (36.7)
Hydrophobic RF	69 (34.2)	51 (26.6)	45 (32.3)	22 (44.9)
RF with stop codon(s)	63 (31.2)	23 (11.9)	43 (31.0)	9 (18.4)

Data are n (%).
^aIn 6 of 198 and 4 of 53 V-D-J in CLL and ALL, respectively, the IGHD gene was not determined.
^bStatistically significant higher frequency for RF2 and hydrophilic RF was observed in productive V-D-J junctions versus productively rearranged D-J joints in CLL (P < 0.001 for both comparisons).

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