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Table 2 TdT and exonuclease activity in productively rearranged IGHD-IGHJ (D-J) versus IGHV-IGHD-IGHJ (V-D-J) in CLL and ALL.

From: Partial versus Productive Immunoglobulin Heavy Locus Rearrangements in Chronic Lymphocytic Leukemia: Implications for B-Cell Receptor Stereotypy

  D-J in CLL V-D-J in CLL D-J in ALL V-D-J in ALL D-J versus V-D-J in CLL (P) D-J versus V-D-J in ALL (P) D-J in CLL versus ALL (P)
TdT activity        
Positivity (%) 96.9 92.0 90.0 89.8 0.03 0.92 0.01
Median number of nucleotides (range) 9 (1–76) 7 (139) 8 (134) 6 (1–81) 0.01 0.96 0.13
3′ IGHD exonuclease activity Positivity (%) 87.6 81.8 88.5 85.7 0.06 0.98 0.52
Median number of nucleotides (range) 4 (124) 4 (119) 4 (125) 5 (116) 0.74 0.12 0.26
5′ IGHJ exonuclease activity Positivity (%) 86.6 86.6 85.4 77.6 0.99 0.08 0.84
Median number of nucleotides (range) 5 (127) 5 (129) 6 (125) 5 (116) 0.39 0.06 0.06