Figure 7
Effect of ING4 downregulation on the in vitro sensitivity of SPC-A1 or A549 cells to DTX or paclitaxel. (A) Real-time quantitative RT-PCR analysis of ING4mRNA expression in the stably transfected SPC-A1/shING4 (or SPC-A1/shcontrol) and A549/shING4 (or A549/shcontrol) cells. (B) Western blot analysis of ING4 protein expression in the stably transfected SPC-A1/shING4 (or SPC-A1/shcontrol) and A549/shING4 (or A549/shcontrol) cells. (C) MTT analysis of the IC50 values of DTX or paclitaxel in SPC-A1/shING4 (or SPC-A1/ shcontrol) and A549/shING4 (or A549/shcontrol) cells. Results represent the average of three independent experiments (mean ± SD). *p < 0.05 and **p < 0.01 compared with SPC-A1/shcontrol or A549/shcontrol cell line.