Molecular Medicine

Table 1 Differentially expressed genes with a >15.0-fold change in the DTX-resistant SPC-A1 cell line (SPC-A1/DTX) compared with the parental SPC-A1 cell line.

From: Identification of ING4 (Inhibitor of Growth 4) as a Modulator of Docetaxel Sensitivity in Human Lung Adenocarcinoma

cDNA expression profiles
Upregulated in SPC-A1/DTX			Downregulated in SPC-A1/DTX
Gene symbol	Fold change^a	P ^b	Gene symbol	Fold change^a	P ^b
PDE1A	99.7	0.003	SERPINB5	60.9	< 0.001
SLC7A7	83.9	0.012	LUM	57.3	0.007
ALDH2	49.9	0.005	ING4	39.4	0.001
BIRC7	41.1	0.004	CYP1A1	33.8	0.003
TESCALCIN	37.5	0.021	RASIP1	24.5	0.006
MUC13	37.5	0.006	RNASEK	22.1	0.011
NOTCH1	34.5	< 0.001	TMPRSS11F	20.4	<0.001
CHST13	34.3	0.009	GALR2	18.7	0.006
STMN3	31.8	<0.001	KRT15	18.5	<0.001
KLHDC9	30.7	0.014	RUNX3	17.8	0.009
UBE2L6	30.5	0.001	ABCG ₂	17.1	0.001
OLFM1	29.7	0.001	ABCC ₃	16.5	0.006
FNDC5	22.8	0.003
PTGDS	21.9	0.005
CTSH	21.0	<0.001
TCAM1P	20.7	0.018
NAP1L5	18.5	0.007
FAM18A	18.5	0.004
KIR2DL1	17.5	0.002

^aFold change values were generated from the median expression of the miRNAs in the groups compared.
^bStudent t test p values.

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ISSN: 1528-3658

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