Propranolol attenuates activation of proximal sensors of hepatic burn-induced UPR. (A) Activation of Bip, IRE-1, PERK and ATF-6 were analyzed in sham, burn and burn + propranolol (Prop) groups. Proteins levels are normalized to GAPDH. (B) Data represent mean ± SEM. #P < 0.05, value for sham versus burn; *P < 0.05, value for burn versus burn + prop 72 h after burn injury. Data are representative of three separate experiments.