Propranolol reduces JNK activation and JNK associated IRS-1 phosphorylation. Activation of JNK (A) and IRS-1 phosphorylation (B) at serine 307 was analyzed in sham, burn and burn + propranolol (Prop) groups. Protein levels were normalized to total levels of protein. Data represent mean ± SEM. #P < 0.05, value for sham versus burn; *P < 0.05, value for burn versus burn + prop 72 h after burn injury. Data are representative of three separate experiments.