Figure 1

Existing versus desirable targeting of transcription factors and interconnected networks in cancer therapeutics. The uppermost schematic depicts the serial phenotypic changes and the accumulated molecular alterations (genetic and epigenetic) during carcinogenesis (breast cancer can be viewed as a typical example). This schematic has been adapted from Karamouzis et al. (40), with permission from Elsevier. BTM, basal transcriptional machinery; TF, transcription factor.