Figure 4

Cochlear volumes. Volume (mean ± SEM, mm³) of the tympanic (ST), media (SM) and vestibular (SV) scalas and the spiral ligament (SpL), stria vascularis (StV) and cochlear ganglion (SG) in wild-type (n = 3), Irs2^−/−Ptpn1^+/+ (n = 4), and Irs2^−/−Ptpn1^−/− (n = 4) mice at 11 wks of age is shown. The smaller size of ST, SM and SpL in IRS2-deficient and double-null mice compared with wild-type mice did not reach significance. However, SG was significantly reduced in size in both IRS2-deficient (*P < 0.05) and double-null mice (^##P < 0.01) compared with wild-type mice; StV also showed a decrease in volume, but only in IRS2-deficient mice (*P < 0.05; **P < 0.01). □, Irs2^+/+Ptpn1^+/+ mice; ■, Irs2^−/−Ptpn1^+/+ mice; ▥, Irs2^−/−Ptpn^−/− mice.