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Table 1 ABR thresholds and latencies.

From: Insulin Receptor Substrate 2 (IRS2)-Deficient Mice Show Sensorineural Hearing Loss That Is Delayed by Concomitant Protein Tyrosine Phosphatase 1B (PTP1B) Loss of Function

  Genotype
  Age 3–5 wks Age 8–16 wks
  Irs2 +/+ Ptpn1 +/+ Irs2 −/− Ptpn1 +/+ Ptpn1 −/− Irs2 +/+ Irs2 −/− Ptpn1 −/− Irs2 +/+ Ptpn1 +/+ Irs2 −/− Ptpn1 +/+ Ptpn1 −/− Irs2 +/+ Irs2 −/− Ptpn1 −/−
n 9 7 10 6 8 18 9 8
ABR threshold (dB SPL)         
Click 39 ± 3 80 ± 10a 36 ± 4 38 ± 3 36 ± 4 79 ± 8a 38 ± 4 69 ± 10a
8 kHz 39 ± 5 73 ± 6a 42 ± 4 42 ± 4 39 ± 6 81 ± 8a 43 ± 5 69 ± 17a
16 kHz 37 ± 7 67 ± 6a 35 ± 12 35 ± 3 35 ± 5 72 ± 10a 37 ± 5 67 ± 12a
20 kHz 39 ± 7 80 ± 10a 41 ± 8 40 ± 8 39 ± 7 82 ± 11a 40 ± 6 71 ± 15a
40 kHz 49 ± 4 90 ± 10a 48 ± 6 50 ± 7 43 ± 5 90 ± 7a 47 ± 8 77 ± 16a
n 9 6 9 6 8 18 9 8
Peak latency (ms)         
I 1.28 ± 0.08 1.39 ± 0.14a 1.35 ± 0.0 1.32 ± 0.06 1.28 ± 0.09 1.32 ± 0.08c 1.30 ± 0.10 1.26 ± 0.09
II 2.16 ± 0.09 2.30 ± 0.13b 2.36 ± 0.07c 2.28 ± 0.05 2.20 ± 0.12 2.17 ± 0.12 2.12 ± 0.10c 2.16 ± 0.04
IV 3.88 ± 0.12 4.14 ± 0.90a 4.48 ± 0.20 4.22 ± 0.09a 3.85 ± 0.15 3.93 ± 0.14 3.83 ± 0.14 3.96 ± 0.15
Interpeak latency (ms)         
I–II 0.87 ± 0.10 0.90 ± 0.05 1.01 ± 0.07c 0.95 ± 0.04b 0.92 ± 0.10 0.84 ± 0.09c 0.82 ± 0.11c 0.90 ± 0.08
II–IV 1.72 ± 0.13 1.84 ± 0.09c 2.12 ± 0.16 1.94 ± 0.06a 1.65 ± 0.14 1.76 ± 0.09c 1.71 ± 0.08 1.79 ± 0.11c
I–IV 2.59 ± 0.09 2.75 ± 0.12c 3.13 ± 0.21 2.89 ± 0.06a 2.57 ± 0.10 2.60 ± 0.13 2.53 ± 0.15 2.69 ± 0.15
  1. ABR thresholds (mean ± SD in dB SPL) in response to click and tone burst (4–40 kHz) stimuli were determined in young (3- to 5-wk-old) and adult (8- to 16-wk-old) mice from the four genotypes analyzed. Click ABR peak and interpeak latencies (mean ± SD, in ms) are shown in the four genotypes studied at the two ages analyzed. Statistically significant differences were found when comparing mutant mice with wild-type mice:
  2. aP < 0.001.
  3. bP < 0.05.
  4. cP < 0.01.