Genotype | ||||||||
---|---|---|---|---|---|---|---|---|
Age 3–5 wks | Age 8–16 wks | |||||||
Irs2 +/+ Ptpn1 +/+ | Irs2 −/− Ptpn1 +/+ | Ptpn1 −/− Irs2 +/+ | Irs2 −/− Ptpn1 −/− | Irs2 +/+ Ptpn1 +/+ | Irs2 −/− Ptpn1 +/+ | Ptpn1 −/− Irs2 +/+ | Irs2 −/− Ptpn1 −/− | |
n | 9 | 7 | 10 | 6 | 8 | 18 | 9 | 8 |
ABR threshold (dB SPL) | ||||||||
Click | 39 ± 3 | 80 ± 10a | 36 ± 4 | 38 ± 3 | 36 ± 4 | 79 ± 8a | 38 ± 4 | 69 ± 10a |
8 kHz | 39 ± 5 | 73 ± 6a | 42 ± 4 | 42 ± 4 | 39 ± 6 | 81 ± 8a | 43 ± 5 | 69 ± 17a |
16 kHz | 37 ± 7 | 67 ± 6a | 35 ± 12 | 35 ± 3 | 35 ± 5 | 72 ± 10a | 37 ± 5 | 67 ± 12a |
20 kHz | 39 ± 7 | 80 ± 10a | 41 ± 8 | 40 ± 8 | 39 ± 7 | 82 ± 11a | 40 ± 6 | 71 ± 15a |
40 kHz | 49 ± 4 | 90 ± 10a | 48 ± 6 | 50 ± 7 | 43 ± 5 | 90 ± 7a | 47 ± 8 | 77 ± 16a |
n | 9 | 6 | 9 | 6 | 8 | 18 | 9 | 8 |
Peak latency (ms) | ||||||||
I | 1.28 ± 0.08 | 1.39 ± 0.14a | 1.35 ± 0.0 | 1.32 ± 0.06 | 1.28 ± 0.09 | 1.32 ± 0.08c | 1.30 ± 0.10 | 1.26 ± 0.09 |
II | 2.16 ± 0.09 | 2.30 ± 0.13b | 2.36 ± 0.07c | 2.28 ± 0.05 | 2.20 ± 0.12 | 2.17 ± 0.12 | 2.12 ± 0.10c | 2.16 ± 0.04 |
IV | 3.88 ± 0.12 | 4.14 ± 0.90a | 4.48 ± 0.20 | 4.22 ± 0.09a | 3.85 ± 0.15 | 3.93 ± 0.14 | 3.83 ± 0.14 | 3.96 ± 0.15 |
Interpeak latency (ms) | ||||||||
I–II | 0.87 ± 0.10 | 0.90 ± 0.05 | 1.01 ± 0.07c | 0.95 ± 0.04b | 0.92 ± 0.10 | 0.84 ± 0.09c | 0.82 ± 0.11c | 0.90 ± 0.08 |
II–IV | 1.72 ± 0.13 | 1.84 ± 0.09c | 2.12 ± 0.16 | 1.94 ± 0.06a | 1.65 ± 0.14 | 1.76 ± 0.09c | 1.71 ± 0.08 | 1.79 ± 0.11c |
I–IV | 2.59 ± 0.09 | 2.75 ± 0.12c | 3.13 ± 0.21 | 2.89 ± 0.06a | 2.57 ± 0.10 | 2.60 ± 0.13 | 2.53 ± 0.15 | 2.69 ± 0.15 |