Time post-APAP treatmenta | 0 h | 5 h | 15 h | 24 h |
---|---|---|---|---|
Histological findings | No abnormalities detected necrosis with mild inflammatory cell infiltration | Centrilobular hepatocyte necrosis with moderate inflammatory cell infiltration (including neutrophil rolling) | Centrilobular hepatocyte detected | No abnormalities |
Serum ALT (U/L)b | 31 ± 10 | 2641 ± 1,024c | 3,015 ± 801c | 3,811 ± 1,514c |
Serum HMGB1 cysteine redox status identified | Molecule A | Molecule A + D | Molecule A + D | Molecule D |