The TPR is characterized by expression of βCR and EPOR. (A) A variety of neurons within rat spinal cord ventral horn express both βCR and EPOR. (B) In this experiment, wildtype rat cardiomyocytes undergo apoptosis after exposure to stuarosporine invitro(column WT). Addition of EPO protects from staurosporine (WT+EPO). In contrast, cardiomyocytes obtained from βCR KO (βc KO) animals are not protected by EPO (βc KO+EPO). (****P< 0.001 versus staurosporine alone; reproduced with adaptation from (35)).