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Figure 5 | Molecular Medicine

Figure 5

From: The Receptor That Tames the Innate Immune Response

Figure 5

The TPR acts a molecular switch activating long-lasting tissue protection. Histamine injected intradermally activates histamine receptors that within several minutes cause intense vasoconstriction at the site of injection (wheal) that is surrounded by extravasated intravascular proteins (flare). (A) This reaction can be quantified by labeling albumin with Evans blue dye. As an example, a rat that received saline 4 h earlier exhibited a vigorous response to histamine (top). In contrast, a rat that received pHBSP 4 h earlier responded with substantially less vascular extravasation, as indicated by the smaller region less intensively labeled with Evans blue (bottom). (B) A single dose of the tissue-protective molecule pHBSP (30 µg/kg) exerts long-Iasting effects, antagonizing histamine administered hours later (top; ± SEM). (Please see text for details.)

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