Figure 4
From: Ymer Acts as a Multifunctional Regulator in Nuclear Factor-κB and Fas Signaling Pathways
Ymer inhibits glomerulonephritis in lpr/lpr mice. (A) The levels of urinary protein in B6-lpr/+;Ymer545, B6-lpr/lpr and B6-lpr/lpr;Ymer545 mice. Urinary proteins were measured during 4–18 wks of age (B6-lpr/+;Ymer545, n = 9; B6-lpr/lpr, n = 10; B6-lpr/lpr;Ymer545, n = 7). (B) Histochemical analysis of glomerulonephritis. Renal tissues were dissected out at 7–8 months of age and used for histochemical analysis with PAS staining. Arrows indicate the proliferation of mesangium cells in the glomerulus. Scale bars indicate 50 µm. (C) Quantification of glomerulonephritis in Ymer Tg mice crossed with lpr mice. The frequency of inflammatory glomerulus in which cells were proliferated in the mesangial region was quantified using B6-lpr;Ymer hybrid mice (B6-lpr/+;Ymer545, n = 7; B6-lpr/lpr, n = 8; B6-lpr/lpr;Ymer545, n = 5). Each dot indicates the score of glomerulonephritis obtained from individual mice. The Welch t test was used to measure differences among samples.