Skip to main content
Figure 6 | Molecular Medicine

Figure 6

From: Ymer Acts as a Multifunctional Regulator in Nuclear Factor-κB and Fas Signaling Pathways

Figure 6

Ymer accelerates the caspase-dependent signal and maintains long-term activation of NF-κB signaling in Fas-stimulated thymocytes. (A) Thymocytes isolated from WT and Ymer545 Tg mice were stimulated with anti-Fas Ab (10 µg/mL) and then probed with the indicated Abs to detect the activation of downstream signaling after stimulation. (B) Time course of cleaved form of PARP in thymocytes from WT and Ymer545 Tg mice after anti-Fas Ab treatment. A relative amount of the cleaved form of PARP at each time in (A) is shown. The value of the chase period at 0 h was defined as 1. (C) Time course of phosphorylated IKKα/β in thymocytes from WT and Ymer545 Tg mice after anti-Fas Ab treatment. Relative amount of phosphorylated IKKα/β at each time in (A) is shown. The value of the chase period at 0 h was defined as 1. (D) Model for biological roles of Ymer. Ymer may have multi-functions for several signaling pathways including TLR4, TNFR and Fas. Ymer attenuates NF-κB signaling downstream of TLR4 and TNFR, whereas it accelerates LPS-induced IFN production and Fas-induced NF-κB and JNK activation for apoptotic cell death.

Back to article page