Table 1 Effect of axitinib on reversing ABCG2-mediated drug resistance.^a

Topetecan

0.250 ± 0.014

(1.00)

12.79 ± 0.241

(1.00)

+0.25 µmol/L Axitinib

0.249 ± 0.020

(1.01)

6.692 ± 0.504^b

(1.85)

+0.5 µmol/L Axitinib

0.255 ± 0.017

(0.98)

4.964 ± 0.320^b

(2.47)

+ 1.0 µmol/L Axitinib

0.199 ± 0.006

(1.26)

3.020 ± 0.242^b

(4.11)

+0.5 µmol/L FTC

0.244 ± 0.013

(1.02)

1.195 ± 0.108^b

(10.7)

Mitoxantrone

0.193 ± 0.021

(1.00)

14.668 ± 0.636

(1.00)

+0.25 µmol/L Axitinib

0.194 ± 0.057

(0.99)

7.992 ± 0.675^b

(1.84)

+0.5 µmol/L Axitinib

0.201 ± 0.011

(0.96)

4.140 ± 0.301^b

(3.54)

+ 1.0 µmol/L Axitinib

0.185 ± 0.011

(1.12)

2.904 ± 0.482^b

(5.05)

+0.5 µmol/L FTC

0.188 ± 0.011

(1.03)

1.272 ± 0.056^b

(11.5)

Cisplatin

14.877 ± 1.126

(1.00)

14.496 ± 1.112

(1.00)

+ 1.0 µmol/L Axitinib

14.206 ± 1.460

(1.05)

14.360 ± 1.812

(1.01)

KB

KBv200(ABCB1)

Doxorubicin

0.024 ± 0.002

(1.00)

2.204 ± 0.108

(1.00)

+0.25 µmol/L Axitinib

0.024 ± 0.002

(1.00)

2.022 ± 0.185

(1.08)

+0.5 µmol/L Axitinib

0.025 ± 0.001

(0.96)

2.153 ± 0.146

(1.02)

+ 1.0 µmol/L Axitinib

0.015 ± 0.004^c

(1.63)

1.250 ± 0.215^c

(1.76)

+ 10 µmol/L Verapamil

0.024 ± 0.003

(1.00)

0.109 ± 0.008^b

(20.2)

Cispatin

1.552 ± 0.121

(1.00)

2.364 ± 0.241

(1.00)

+ 1.0 µmol/L Axitinib

1.514 ± 0.117

(1.03)

2.412 ± 0.225

(0.98)

HL60

HL60/ADR(ABCC1)

Doxorubicin

0.055 ± 0.011

(1.00)

5.725 ± 0.203

(1.00)

+0.1 µmol/L Axitinib

0.054 ± 0.006

(1.02)

5.719 ± 0.591

(1.00)

+0.2 µmol/L Axitinib

0.056 ± 0.006

(0.98)

5.759 ± 0.659

(0.99)

+0.4 µmol/L Axitinib

0.049 ± 0.005

(1.13)

5.476 ± 0.384

(1.04)

+40 µmol/L MK571

0.054 ± 0.005

(1.02)

1.108 ± 0.182^b

(5.17)

Cisplatin

1.456 ± 0.187

(1.00)

1.658 ± 0.118

(1.00)

+0.4 µmol/L Axitinib

1.516 ± 0.125

(0.96)

1.524 ± 0.175

(1.08)

SW1573

SW1573/2R120(LRP)

Doxorubicin

0.108 ± 0.012

(1.00)

1.266 ± 0.121

(1.00)

+0.25 µmol/L Axitinib

0.096 ± 0.004

(1.12)

1.214 ± 0.174

(1.04)

+0.5 µmol/L Axitinib

0.098 ± 0.004

(1.10)

1.236 ± 0.122

(1.02)

+ 1.0 µmol/L Axitinib

0.094 ± 0.006

(1.14)

1.138 ± 0.088

(1.11)

Cisplatin

2.473 ± 0.167

(1.00)

9.659 ± 1.073

(1.00)

+ 1.0 µmol/L Axitinib

2.790 ± 0.147

(0.89)

9.180 ± 0.881

(1.05)

NIH3T3

NIH3T3/MRP4-2(ABCC4)

6-MP

0.298 ± 0.050

(1.00)

11.852 ± 1.564

(1.00)

+0.25 µmol/L Axitinib

0.285 ± 0.034

(1.04)

11.145 ± 1.048

(1.06)

+0.5 µmol/L Axitinib

0.318 ± 0.045

(0.94)

10.709 ± 1.637

(1.11)

+ 1.0 µmol/L Axitinib

0.265 ± 0.011

(1.12)

12.319 ± 1.704

(0.96)

Cisplatin

6.140 ± 0.728

(1.00)

5.668 ± 0.690

(1.00)

+ 1.0 µmol/L Axitinib

5.033 ± 0.296

(1.21)

5.842 ± 0.691

(0.97)