Compounds | IC50 ± SD, µmol/L (Fold reversal) | |||
---|---|---|---|---|
S1 | S1-M1-80(ABCG2) | |||
Topetecan | 0.250 ± 0.014 | (1.00) | 12.79 ± 0.241 | (1.00) |
+0.25 µmol/L Axitinib | 0.249 ± 0.020 | (1.01) | 6.692 ± 0.504b | (1.85) |
+0.5 µmol/L Axitinib | 0.255 ± 0.017 | (0.98) | 4.964 ± 0.320b | (2.47) |
+ 1.0 µmol/L Axitinib | 0.199 ± 0.006 | (1.26) | 3.020 ± 0.242b | (4.11) |
+0.5 µmol/L FTC | 0.244 ± 0.013 | (1.02) | 1.195 ± 0.108b | (10.7) |
Mitoxantrone | 0.193 ± 0.021 | (1.00) | 14.668 ± 0.636 | (1.00) |
+0.25 µmol/L Axitinib | 0.194 ± 0.057 | (0.99) | 7.992 ± 0.675b | (1.84) |
+0.5 µmol/L Axitinib | 0.201 ± 0.011 | (0.96) | 4.140 ± 0.301b | (3.54) |
+ 1.0 µmol/L Axitinib | 0.185 ± 0.011 | (1.12) | 2.904 ± 0.482b | (5.05) |
+0.5 µmol/L FTC | 0.188 ± 0.011 | (1.03) | 1.272 ± 0.056b | (11.5) |
Cisplatin | 14.877 ± 1.126 | (1.00) | 14.496 ± 1.112 | (1.00) |
+ 1.0 µmol/L Axitinib | 14.206 ± 1.460 | (1.05) | 14.360 ± 1.812 | (1.01) |
 | KB | KBv200(ABCB1) | ||
Doxorubicin | 0.024 ± 0.002 | (1.00) | 2.204 ± 0.108 | (1.00) |
+0.25 µmol/L Axitinib | 0.024 ± 0.002 | (1.00) | 2.022 ± 0.185 | (1.08) |
+0.5 µmol/L Axitinib | 0.025 ± 0.001 | (0.96) | 2.153 ± 0.146 | (1.02) |
+ 1.0 µmol/L Axitinib | 0.015 ± 0.004c | (1.63) | 1.250 ± 0.215c | (1.76) |
+ 10 µmol/L Verapamil | 0.024 ± 0.003 | (1.00) | 0.109 ± 0.008b | (20.2) |
Cispatin | 1.552 ± 0.121 | (1.00) | 2.364 ± 0.241 | (1.00) |
+ 1.0 µmol/L Axitinib | 1.514 ± 0.117 | (1.03) | 2.412 ± 0.225 | (0.98) |
 | HL60 | HL60/ADR(ABCC1) | ||
Doxorubicin | 0.055 ± 0.011 | (1.00) | 5.725 ± 0.203 | (1.00) |
+0.1 µmol/L Axitinib | 0.054 ± 0.006 | (1.02) | 5.719 ± 0.591 | (1.00) |
+0.2 µmol/L Axitinib | 0.056 ± 0.006 | (0.98) | 5.759 ± 0.659 | (0.99) |
+0.4 µmol/L Axitinib | 0.049 ± 0.005 | (1.13) | 5.476 ± 0.384 | (1.04) |
+40 µmol/L MK571 | 0.054 ± 0.005 | (1.02) | 1.108 ± 0.182b | (5.17) |
Cisplatin | 1.456 ± 0.187 | (1.00) | 1.658 ± 0.118 | (1.00) |
+0.4 µmol/L Axitinib | 1.516 ± 0.125 | (0.96) | 1.524 ± 0.175 | (1.08) |
 | SW1573 | SW1573/2R120(LRP) | ||
Doxorubicin | 0.108 ± 0.012 | (1.00) | 1.266 ± 0.121 | (1.00) |
+0.25 µmol/L Axitinib | 0.096 ± 0.004 | (1.12) | 1.214 ± 0.174 | (1.04) |
+0.5 µmol/L Axitinib | 0.098 ± 0.004 | (1.10) | 1.236 ± 0.122 | (1.02) |
+ 1.0 µmol/L Axitinib | 0.094 ± 0.006 | (1.14) | 1.138 ± 0.088 | (1.11) |
Cisplatin | 2.473 ± 0.167 | (1.00) | 9.659 ± 1.073 | (1.00) |
+ 1.0 µmol/L Axitinib | 2.790 ± 0.147 | (0.89) | 9.180 ± 0.881 | (1.05) |
 | NIH3T3 | NIH3T3/MRP4-2(ABCC4) | ||
6-MP | 0.298 ± 0.050 | (1.00) | 11.852 ± 1.564 | (1.00) |
+0.25 µmol/L Axitinib | 0.285 ± 0.034 | (1.04) | 11.145 ± 1.048 | (1.06) |
+0.5 µmol/L Axitinib | 0.318 ± 0.045 | (0.94) | 10.709 ± 1.637 | (1.11) |
+ 1.0 µmol/L Axitinib | 0.265 ± 0.011 | (1.12) | 12.319 ± 1.704 | (0.96) |
Cisplatin | 6.140 ± 0.728 | (1.00) | 5.668 ± 0.690 | (1.00) |
+ 1.0 µmol/L Axitinib | 5.033 ± 0.296 | (1.21) | 5.842 ± 0.691 | (0.97) |