Table 2 Effect of axitinib on reversing ABCG2-mediated MDR in transfected cell lines.^a

Mitoxantrone

0.029 ± 0.0015

(1.00)

1.176 ± 0.241

(1.00)

1.195 ± 0.301

(1.00)

+0.25 µmol/L Axitinib

0.031 ± 0.0024

(0.94)

0.488 ± 0.085^b

(2.41)

0.338 ± 0.028^b

(3.54)

+0.5 µmol/L Axitinib

0.041 ± 0.0029

(0.71)

0.247 ± 0.076^b

(4.76)

0.206 ± 0.013^b

(5.80)

+ 1.0 µmol/L Axitinib

0.042 ± 0.0033

(0.70)

0.079 ± 0.007^b

(14.9)

0.076 ± 0.005^b

(15.7)

+0.5 µmol/L FTC

0.040 ± 0.0011

(0.73)

0.138 ± 0.005^b

(8.52)

0.096 ± 0.003^b

(12.4)

Cisplatin

4.069 ± 0.258

(1.00)

5.141 ± 0.197

(1.00)

4.324 ± 0.176^b

(1.00)

+ 1.0 µmol/L Axitinib

5.449 ± 0.269

(0.75)

4.512 ± 0.224

(1.14)

5.078 ± 0.209^b

(0.85)