Figure 2

Effect of tunicamycin (TN) on cardiac mechanical properties in WT mice and ALDH2 KO mice. An M-mode representation (A) is shown that clearly indicated the depressed cardiac mechanical properties. Ejection fraction (EF) (B) and fractional shortening (FS) (C) were decreased in ALDH2 KO mice compared with WT mice. LVESD (D) was increased in ALDH2 KO mice compared with WT mice after TN challenge. (E) There is no significantly statistical difference in LVEDD between groups. Data are mean ± SEM; n = 5 per group. *p < 0.05 versus WT group; ^#p < 0.05 versus ALDH2 KO-TN group.