Figure 1
From: Statins Induce the Accumulation of Regulatory T Cells in Atherosclerotic Plaque
Simvastatin promoted the numbers of Tregs and the expression of Treg markers in atherosclerotic plaques. (A) Tregs were visualized (blue color for 4′,6-diamidino-2-phenylindole (DAPI) staining nuclei and green color depicted Foxp3+ Tregs). (B) mRNA expression of Foxp3 in atherosclerotic plaques of two groups of mice. (C) Protein expression of Foxp3 in atherosclerotic plaques of two groups of mice by Western blot. (D) Quantitative analysis of the results in (C). (E) mRNA expression of TGF-β in atherosclerotic plaques of two groups of mice. (F) Protein expression of TGF-β in atherosclerotic plaques of two groups of mice by Western blot. (G) Quantitative analysis of the results in (F). (H) mRNA expression of IL-10 in atherosclerotic plaques of two groups of mice. (I) Protein expression of IL-10 in atherosclerotic plaques of two groups of mice by Western blot. (J) Quantitative analysis of the results in (I). *P < 0.05 versus control group. C, control group; S, simvastatin group.