Figure 5
From: Statins Induce the Accumulation of Regulatory T Cells in Atherosclerotic Plaque
Simvastatin improved the proportion and regulatory function of Tregs in PBMCs from ACS patients. (A) Representative FACS analysis of percentage CD4+CD25+Foxp3+ Tregs to total CD4+ cells in the control group. (B) Representative FACS analysis of percentage CD4+CD25+Foxp3+ Tregs to total CD4+ cells in 1 µmol/L simvastatin group. (C) Representative FACS analysis of percentage CD4+CD25+Foxp3+ Tregs to total CD4+ cells in the 10 µmol/L simvastatin group. (D) FACS analysis results: percentage CD4+CD25+Foxp3+ Tregs to total CD4+ cells in three groups of PBMCs. (E) Purified Tregs and CD4+CD25− cells from PBMCs were incubated at different ratios (Tregs:CD4+CD25− cells = 1:1, 1:2, 1:4, 1:8) without (control) or with simvastatin. [3H]-thymidine was added and proliferation was evaluated. *P < 0.05 versus control group. #P < 0.05 versus 1 µmol/L simvastatin group.