Skip to main content
Figure 3 | Molecular Medicine

Figure 3

From: Mice with a D190N Mutation in the Gene Encoding Rhodopsin: A Model for Human Autosomal-Dominant Retinitis Pigmentosa

Figure 3

Reduced photoreceptor scotopic ERG a-wave amplitudes show diminished rod function. Scotopic ERG responses were recorded in two patients and a healthy control. The amplitude of the a-wave (A) was reduced in affected patients at bright intensities, whereas the amplitude of the b-wave (B) was reduced at all light intensities. In D190N/+ mice at both P21 and P100, scotopic a-waves were reduced in comparison to wt, consistent with desensitization of the rod response (C, E). The b-wave in the scotopic test did not significantly differ between D190N/+ and control at P21 (D), although at P100 the difference in the b-wave amplitude was significant (F). Data were composed by measuring the average of different animals (n ≥ 3). Error bars represent standard error of the mean. *P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.001.

Back to article page