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Figure 4 | Molecular Medicine

Figure 4

From: Mice with a D190N Mutation in the Gene Encoding Rhodopsin: A Model for Human Autosomal-Dominant Retinitis Pigmentosa

Figure 4

OCT and histology demonstrate slow photoreceptor degeneration in patients and animal models. When compared with a healthy individual (A), young patients (B, C) do not present a difference in ONL thickness on SD-OCT. The oldest patient (D) showed IS/OS loss and diminished ONL as well as cystoid macular edema. H&E-stained paraffin sections of wt and D190N/+ at P21 (E, F) and P210 (G, H) were prepared. Compared to the wt mice at P21 (E), D190N/+ presents slightly reduced ONL thickness and diminished OS length (F). Mutant mice at P210 (H) show a loss of four rows of photoreceptor nuclei compared with age-matched control (G). GCL, ganglion cell layer; INL, inner nuclear layer. Scale bar: 50 pm.

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Molecular Medicine

ISSN: 1528-3658