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Figure 5 | Molecular Medicine

Figure 5

From: Distinct Innate Immunity Pathways to Activation and Tolerance in Subgroups of Chronic Lymphocytic Leukemia with Distinct Immunoglobulin Receptors

Figure 5

Differential responses to TLR and NOD2 stimulation in cases using the IGHV4-34 gene and assigned or not to certain stereotyped subsets. (A) Statistically significant differences were identified after stimulation of TLR1/2, TLR2/6, TLR9 and NOD2 with the respective ligands in different IGHV4-34-expressing CLL cases with stereotyped BCRs assigned to subsets #4 versus non-#4/16 BCRs (N). (B) Statistically significant differences were also identified after stimulation of TLR1/2 and TLR2/6 with the respective ligands in different IGHV4-34-expressing CLL cases with stereotyped BCRs assigned to subsets #16 versus non-#4/16 BCRs (N). Whisker boxes (minimum to maximum) represent only the statistically significant differences. Before statistical analysis values were normalized to the unstimulated controls. C, CpG ODN 2006; P Pam3CSK4; M, MALP-2; *p < 0.05, **p < 0.005.

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Molecular Medicine

ISSN: 1528-3658