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Table 1 Summary of corrector efficacy from FAP labeling and functional assays.

From: Pharmacological Rescue of the Mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Detected by Use of a Novel Fluorescence Platform

 

FAP-F508del-CFTR

F508del-CFTR EL4-FAP

HBE F508del-CFTR

DMSO

0.34

0.37

0.18

C4

0.53

0.51

0.25

CFFT-002

0.55

0.48

0.5

C18

1

1

1

C4 + CFFT-002

0.68

0.52

0.58

C4 + C18

2.11

1.29

0.96

C18 + CFFT-002

1.97

1.37

1.3

  1. The corrector efficacy for single compounds and combinations summarized from Figures 7B, C and D is shown. Results are mean value normalized to C18.