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Table 2 Overview of hepatic histological changes (extent of hepatic damage determined by serum ALT activity) induced by acetaminophen over time in mice and corresponding serum HMGB1 redox status.

From: Erratum to: Redox Modification of Cysteine Residues Regulates the Cytokine Activity of High Mobility Group Box-1 (HMGB1)

Time post-APAP treatmenta

0 h

5 h

15 h

24 h

Histological findings

No abnormalities detected

Centrilobular hepatocyte necrosis with mild inflammatory cell infiltration

Centrilobular hepatocyte necrosis with moderate inflammatory cell infiltration (including neutrophil rolling)

No abnormalities detected

Serum ALT (U/L)b

31 ± 10

2641 ± 1,024c

3,015 ± 801c

3,811 ± 1,514c

Serum HMGB1 cysteine redox status identified

Molecule A

Molecule A + D

Molecule A + D

Molecule D

  1. aThe corresponding LC-MS/MS characterized redox status of each cysteine within circulating HMGB1 also is given for each time point.
  2. bData are presented as mean ± SEM with six animals per group.
  3. cP < 0.01 versus 0 h.