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Figure 2 | Molecular Medicine

Figure 2

From: The Infective Polymerization of Conformationally Unstable Antithrombin Mutants May Play a Role in the Clinical Severity of Antithrombin Deficiency

Figure 2

Infectivity of antithrombin polymers and P1 variants. (A) Immunostaining and autoradiography of 2.5 μmol/L 125I-radiolabeled WT antithrombin added to WT polymers. B) Autoradiography of 2.5 μmol/L 125I-radiolabeled WT antithrombin added to 2.5 μmol/L purified antithrombin London (Δ393) after 3 d incubated at 42°C. C) Polymerization of 2.5 μmol/L 125I-radiolabeled WT antithrombin added to 1µL control plasma and 1μL plasma of carriers of P1 mutants heated at 42°C up to 3 d. Samples were run in native gels. Arrows indicate monomer (M), dimer (D) and trimer (T).

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Molecular Medicine

ISSN: 1528-3658