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Table 1 Anti-FXa activity in plasma of patients carrying P1 mutations and controls after 3 d of incubations at 37°C and 42°C.a

From: The Infective Polymerization of Conformationally Unstable Antithrombin Mutants May Play a Role in the Clinical Severity of Antithrombin Deficiency

  Anti-FXa activity, %b  
  37°C 42°C Activity reduction, %c
Control 100.0 ± 5.1 73.5 ± 3.7 26.5
A393 47.8 ± 2.3 28.4 ± 2.2 40.6
R393H 54.8 ± 1.8 21.3 ± 3.5 61.1
R393C 50.5 ± 1.1 25.3 ± 4.1 49.9
  1. aData are mean ± SD of three independent measurements.
  2. bPercentage of the activity observed in a pool of 100 healthy subjects.
  3. cReduction of activity induced by heating at 42°C and considering the value observed at 37°C for control plasma as 100%.
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Molecular Medicine

ISSN: 1528-3658