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Table 1 Anti-FXa activity in plasma of patients carrying P1 mutations and controls after 3 d of incubations at 37°C and 42°C.a

From: The Infective Polymerization of Conformationally Unstable Antithrombin Mutants May Play a Role in the Clinical Severity of Antithrombin Deficiency

 

Anti-FXa activity, %b

 
 

37°C

42°C

Activity reduction, %c

Control

100.0 ± 5.1

73.5 ± 3.7

26.5

A393

47.8 ± 2.3

28.4 ± 2.2

40.6

R393H

54.8 ± 1.8

21.3 ± 3.5

61.1

R393C

50.5 ± 1.1

25.3 ± 4.1

49.9

  1. aData are mean ± SD of three independent measurements.
  2. bPercentage of the activity observed in a pool of 100 healthy subjects.
  3. cReduction of activity induced by heating at 42°C and considering the value observed at 37°C for control plasma as 100%.
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Molecular Medicine

ISSN: 1528-3658