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Figure 1 | Molecular Medicine

Figure 1

From: Different Partners, Opposite Outcomes: A New Perspective of the Immunobiology of Indoleamine 2,3-Dioxygenase

Figure 1

Structure view of human IDO. Putative ITIM1 and ITIM2 in human IDO are localized close to each other outside the catalytic domain. Human IDO folds into a catalytic large C-terminal domain, a non-catalytic small N-terminal domain and a long loop connecting the two domains. Green cylinders represent a-helices and orange arrows indicate β-sheets. ITIM1 and ITIM2, highlighted in pink, are located within the α-D helix of the small domain and the β-sheet of the interconnecting loop, respectively. Image (PDB code 2D0T_A) was generated using a Cn3D structure viewer.

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