(A) Perioperative time course of serum MIF levels in cardiac surgical patients (n = 52 until first POD). The dashed line indicates the mean value of MIF as obtained in a healthy control group. (B) Comparison of perioperative time course of serum MIF values between male (n = 35) and female (n = 17) patients. (C) Comparison of perioperative time course of serum MIF values between young (age 46 ± 8 years; n = 12) and old patients (age 71 ± 6 years; n = 40). Data are presented as mean ± SEM. *p < 0.05, **p < 0.01 versus baseline.