Figure 4From: A CYP26B1 Polymorphism Enhances Retinoic Acid Catabolism and May Aggravate AtherosclerosisIncreased efficiency of cellular retinoic acid catabolism by the minor CYP26B1 variant. Plasmid constructs containing the major or minor variant of rs2241057 were transfected into COS-1 cells and THP-1 macrophagelike cells, and levels of the 55-kDa CYP26B1 were determined by Western blot in COS-1 cells (A). Cellular levels of supplemented (3H)atRA were measured by HPLC in COS-1 cells (B) and THP-1 cells (C). Values are relative to protein concentration and SEAP activity, and shown as mean ± SD. **P < 0.01, ***P < 0.001.Back to article page