Figure 4
IL-4 deficiency impairs TH2 and M2 immune response after UUO. IL-13 levels (A), TGF-β mRNA (B) and protein (C) expression and arginase-1 activity (D) in IL-4, IL-12 KO and WT mice submitted to UUO. Percentage of CD11bhigh cells expressing CD206 (E) and MIG (F) in the kidney of mice subjected to UUO. qPCR was normalized to HPRT, and the mean of the WT control mice was considered 1. Dashed line represents WT animals not submitted to UUO. *p < 0.05, **p < 0.01.