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Figure 4 | Molecular Medicine

Figure 4

From: Augmenter of Liver Regeneration (ALR) Is a Novel Biomarker of Hepatocellular Stress/Inflammation: In Vitro, In Vivo and In Silico Studies

Figure 4

ALR is elevated in a mouse model of hemorrhagic shock, followed by resuscitation. C57BL/6 mice (three to four per time point) were subjected to hemorrhagic shock, followed by resuscitation for the indicated time points as described in Materials and Methods. The mice were euthanized by exsanguination under excess inhalation anesthesia and plasma obtained for measurement of ALR. (A) The line indicates predictions of “damage/dysfunction” induced by inflammatory stimuli after hemorrhagic shock, by using a mathematical model of acute inflammation (25). The time course of changes in serum ALR (shown in symbols) closely approximates that predicted for damage/dysfunction in the mathematical model. The damage/dysfunction variable in this model represents “alarm/danger” signals. (B, C) IL-6 and TNF-α in serum at the times indicated after hemorrhagic shock and resuscitation. *p < 0.05 versus 0 time control.

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