Figure 2

Cognitive and behavioral assessments of sepsis surviving mice. (A) Mice (CLP, n = 20, sham surgery, n = 20) were assessed for their ability to find the exit (indicated by a white box in the top view of the clock maze) in the spatial task. (B) CLP-surviving mice needed significantly more time to exit the maze at 1 month and 4 months following insult (**P < 0.01). (C) Sham surgery and CLP mice behaved equivalently in the primary screen as shown by their scores in muscle and spinal function, spinocerebellar function, sensory function, neuropsychiatric function and autonomic function at 1 month following CLP or sham surgery (see Methods for details). Sham surgery and CLP mice behaved (D) equivalently on the rotarod task, (E) exhibited equivalent locomotion and (F) displayed a similar level of anxiety in the black-white alley.