Figure 3
From: HMGB1 Mediates Cognitive Impairment in Sepsis Survivors
Preservation of memory function by neutralizing HMGB1 (A) Neutralizing anti-HMGB1 antibody was administered to CLP mice at 1 wk after sepsis. Serum levels of HMGB1 were analyzed at 4 wks after CLP (*P < 0.05). (B) CLP mice were given anti-HMGB1 monoclonal antibody or isotype control antibody and subjected to the clock maze task. (C) Mice receiving anti-HMGB1 antibody performed significantly better than those receiving control antibody (**P < 0.01).