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Figure 1 | Molecular Medicine

Figure 1

From: CSE1L, a Novel Microvesicle Membrane Protein, Mediates Ras-Triggered Microvesicle Generation and Metastasis of Tumor Cells

Figure 1

v-H-ras triggers microvesicle biogenesis. (A) Representative micrographs of B16F10, B16-dEV and B16-Ras cells. (B) Representative image shows the presence of developing microvesicles at the invadopodia (arrowhead) and the membrane (arrow) of B16-Ras cells. (C) Immunoblotting of phospho-ERK and total ERK in cell lysates from B16-dEV and B16-Ras cells treated with DMSO or PD98059 for 12 h. Band intensities were quantified by densitometry, and the ratio of phosphor-ERK to total ERK is shown. (D) Representative micrographs of B16-dEV and B16-Ras cells treated with DMSO or PD98059 in medium without FBS for 12 h. Note that PD98059 treatment inhibited microvesicle biogenesis induced by v-H-ras.

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Molecular Medicine

ISSN: 1528-3658