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Figure 5 | Molecular Medicine

Figure 5

From: CSE1L, a Novel Microvesicle Membrane Protein, Mediates Ras-Triggered Microvesicle Generation and Metastasis of Tumor Cells

Figure 5

CSE1L mediates metastasis of tumor cells induced by v-H-ras. (A) Representative images show colocalization of CSE1L (arrowheads) with MMP-2 (arrows) in microvesicles analyzed by immunofluorescence with anti-CSE1L and anti-MMP-2 antibodies. (B) Animal models showed CSE1L mediated metastasis of B16F10 melanoma cells induced by v-H-ras. Upper half is a representative photograph of the pulmonary tumors of C57BL/6 mice injected with B16-dEV, B16-CSE1L, B16-Ras and B16-Ras/anti-CSE1L cells. P = 0.06 between mice injected with B16-CSE1L and B16-dEV cells. P = 0.03 between mice injected with B16-Ras and B16-dEV cells. P = 0.02 between mice injected with B16-Ras/anti-CSE1L and B16-dEV cells. P = 0.01 between mice injected with B16-Ras and B16-Ras/anti-CSE1L cells. (C) Growth curves of B16-dEV, B16-CSE1L, B16-Ras and B16-Ras/anti-CSE1L cells. The graph represents the results of three independent assays.

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