Skip to main content

Table 2 Absolute numbers of peptide-reactive T cells in the periphery (per 150,000 cells pre-/postvaccination).

From: High Immune Response Rates and Decreased Frequencies of Regulatory T Cells in Metastatic Renal Cell Carcinoma Patients after Tumor Cell Vaccination

Patient TYMS IGF-BP3 RGS-5 VEGF MMP7 CA IX PRUNE TIF1 NY-ESO Pool Ca Pool Eb DTH
MR-1 51/41c 43/32 d-/16 45/85 14/43e −/24 nd/nd 22/nd 81/112 −/15 12/51 +
MR-2 12/45 64/183 49/135 22/124 48/162 −/65 −/66 50/82 24/173 19/107 39/157 ++
MR-4 23/70 38/107 123/40 80/70 76/157 −/29 105/58 nd/73 40/63 66/71 99/97 +
MR-5 −/17 −/60 19/41 32/41 24/42 −/23 nd/nd −/37 −/64 −/64 13/73 +
MR-6f 12/27 30/48 49/18 −/− −/− −/− −/− −/− −/− −/− −/11
MR-7f −/− −/− −/50 −/13 −/46 −/− nd/nd 13/55 −/− 22/126 15/46 +
MR-9f −/− −/− −/− −/− −/28 −/− −/− −/− −/12 15/31 39/37 (+)
MR-10 60/20 64/13 82/49 77/33 56/45 32/− 32/19 89/57 69/29 69/54 123/155 (+)
MR-11 −/39 99/37 −/43 51/nd −/− 42/− −/− 29/46 142/255 52/107 128/210 +
MR-13 28/46 71/80 40/62 61/32 111/17 −/− −/− 40/101 80/32 41/74 157/125 ++
MR-14 23/36 76/141 39/49 −/126 −/64 28/33 −/14 52/67 16/44 −/63 12/70 ++
MR-15 11/− −/28 −/15 −/59 15/25 −/− −/25 4/53 14/31 −/14 −/67 +
  1. DTH, delayed-type hypersensitivity reaction; nd, not determined (not enough cells).
  2. aPool C contains the peptides for ORMDL3, AHNAK-rel, BTG1, PIG10, LENG4, CP and PRAME.
  3. bPool E contains the peptides for TIF1, CLIC1, ELAC2 and TMP1.
  4. cThe values represent absolute numbers of spots for pre- and postvaccination (pre/post) responses. These values are given after subtraction of background responses (that is, without peptide or with irrelevant Bcr/Abl peptide). The highest postvaccination response is given irrespective of the time point postvaccination (that is, at 6, 14, 22 or 36 wks).
  5. dNo values mean no reactivity (≤10 spots above background, which corresponds to a frequency of ≤1 = 1.5 × 104 IFN-γ-secreting peptide-specific T cells).
  6. eValues representing a greater than two-fold increase in reactivity against the peptides postversus prevaccination are indicated in bold. With the larger peptide pools, a reactivity of ≥40 spots above background was considered positive.
  7. fShort protocol of vaccination starting with the middle dose of 107 vaccine cells. DTH reactivity: −, negative; (+), weak; +, positive; ++, positive (>2 cm redness and/or induration).