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Figure 4 | Molecular Medicine

Figure 4

From: Female Mice Are More Susceptible to Nonalcoholic Fatty Liver Disease: Sex-Specific Regulation of the Hepatic AMP-Activated Protein Kinase-Plasminogen Activator Inhibitor 1 Cascade, but Not the Hepatic Endotoxin Response

Figure 4

Sex differences in hepatic insulin receptor as well as IRS-1 and -2 mRNA expression levels and concentration of active PAI-1 in mice with steatosis induced by feeding a 30% fructose solution. Expression levels of (A) insulin receptor (InsR), (B) IRS-1, and (C) IRS-2 in livers of male and female mice. (D) Hepatic PAI-1 protein concentration. Expression of mRNA was determined by real time RT-PCR with Ī²-actin as a reference gene in the liver. Data are shown as means Ā± SEM (n = 6) and are specified as -fold induction. Cā€”water (control); Fā€”30% fructose solution. **p < 0.01 compared with respective water-fed control mice.

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